{"id":5916,"date":"2026-03-21T16:52:05","date_gmt":"2026-03-21T16:52:05","guid":{"rendered":"https:\/\/kosovatimes.info\/?p=5916"},"modified":"2026-03-21T16:52:05","modified_gmt":"2026-03-21T16:52:05","slug":"fillojne-testet-e-barnave-kunder-plakjes-ne-shba","status":"publish","type":"post","link":"https:\/\/kosovatimes.info\/index.php\/2026\/03\/21\/fillojne-testet-e-barnave-kunder-plakjes-ne-shba\/","title":{"rendered":"Fillojn\u00eb Testet e Barnave Kund\u00ebr Plakjes n\u00eb SHBA"},"content":{"rendered":"\n<p>Administrata Amerikane e Ushqimit dhe Barnave (FDA) i ka dh\u00ebn\u00eb Life Biosciences miratimin p\u00ebr faz\u00ebn I t\u00eb provave klinike tek njer\u00ebzit t\u00eb nj\u00eb terapie gjenetike kund\u00ebr plakjes t\u00eb quajtur ER-100. Ato do t\u00eb fillojn\u00eb me trajtimin e ndryshimeve t\u00eb lidhura me mosh\u00ebn n\u00eb sy. Disa tashm\u00eb po e krahasojn\u00eb k\u00ebt\u00eb moment historik p\u00ebr shkenc\u00ebn e plakjes me lan\u00e7imin e Sputnik I &#8211; nj\u00eb p\u00ebrparim q\u00eb mund t\u00eb ndryshoj\u00eb gjith\u00e7ka. Por a \u00ebsht\u00eb v\u00ebrtet k\u00ebshtu? KP.RU, s\u00eb bashku me ekspert\u00eb, e shqyrtoi \u00e7\u00ebshtjen.<\/p>\n\n\n\n<p>\u00c7far\u00eb \u00ebsht\u00eb ER-100 dhe pse \u00ebsht\u00eb m\u00eb shum\u00eb sesa thjesht nj\u00eb \u201cpilul\u00eb rinore\u201d?<br>ER-100 \u00ebsht\u00eb nj\u00eb terapi gjenetike e projektuar posa\u00e7\u00ebrisht p\u00ebr t\u00eb luftuar procesin e plakjes.<\/p>\n\n\n\n<p>Bart\u00ebsi i virusit t\u00eb inaktivizuar u d\u00ebrgon qelizave tre gjene ky\u00e7e &#8211; OCT4, SOX2 dhe KLF4. K\u00ebto gjene jan\u00eb pjes\u00eb e &#8220;koktejit t\u00eb famsh\u00ebm Yamanaka&#8221;, zbulimi i t\u00eb cilit i fitoi shkenc\u00ebtarit japonez Shinya Yamanaka \u00c7mimin Nobel n\u00eb Fiziologji ose Mjek\u00ebsi n\u00eb vitin 2012.<\/p>\n\n\n\n<p>Si ndodh p\u00ebrt\u00ebritja?<br>Qelizat e rritura, n\u00ebn ndikimin e k\u00ebtyre &#8220;faktor\u00ebve Yamanaka&#8221;, mund t\u00eb &#8220;riprogramohen&#8221; dhe t\u00eb kthehen n\u00eb nj\u00eb gjendje t\u00eb ngjashme me qelizat burimore embrionale.<\/p>\n\n\n\n<p>Megjithat\u00eb, nj\u00eb kthim i plot\u00eb n\u00eb nivelin e qelizave staminale \u00ebsht\u00eb i rreziksh\u00ebm, pasi rreziku i tumoreve rritet ndjesh\u00ebm. Prandaj, zhvilluesit n\u00eb Life Biosciences dol\u00ebn me nj\u00eb metod\u00eb t\u00eb quajtur riprogramim i pjessh\u00ebm.<\/p>\n\n\n\n<p>Qelizat nuk shnd\u00ebrrohen n\u00eb &#8220;qeliza foshnjore&#8221;, por thjesht hedhin posht\u00eb &#8220;prishjet&#8221; epigjenetike t\u00eb akumuluara gjat\u00eb viteve.<\/p>\n\n\n\n<p>&#8220;Fakti \u00ebsht\u00eb se me mosh\u00ebn, ndryshimet epigjenetike grumbullohen n\u00eb qeliza &#8211; &#8220;sh\u00ebnuesit&#8221; kimik\u00eb n\u00eb ADN q\u00eb rregullojn\u00eb funksionin e gjeneve nd\u00ebrpriten. Besohet se riprogramimi i pjessh\u00ebm mund t&#8217;i rikthej\u00eb k\u00ebto ndryshime dhe t&#8217;i kthej\u00eb qelizat n\u00eb nj\u00eb gjendje m\u00eb rinore&#8221;, shpjegon endokrinologia, MD dhe studiuese e lart\u00eb n\u00eb Fakultetin e Mjek\u00ebsis\u00eb Themelore n\u00eb Universitetin Shtet\u00ebror t\u00eb Mosk\u00ebs, Zukhra Pavlova, n\u00eb kanalin e saj n\u00eb Telegram, &#8220;Doktoresha Pavlova, Endokrinologe&#8221;.<\/p>\n\n\n\n<p>Pse fillojn\u00eb t\u00eb testojn\u00eb me sy?<br>Ka arsye p\u00ebr k\u00ebt\u00eb zgjedhje:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Syri \u00ebsht\u00eb nj\u00eb organ relativisht i izoluar, ila\u00e7i administrohet lokalisht (me injeksion) dhe rreziku i efekteve sistemike \u00ebsht\u00eb minimal.<\/li>\n\n\n\n<li>Rezultatet jan\u00eb t\u00eb dukshme menj\u00ebher\u00eb: mpreht\u00ebsia vizuale, fusha vizuale dhe gjendja e retin\u00ebs mund t\u00eb maten me instrumente.<\/li>\n<\/ul>\n\n\n\n<p>&#8220;Shum\u00eb s\u00ebmundje t\u00eb syrit jan\u00eb nj\u00eb rast klasik i plakjes qelizore. N\u00ebse terapia funksionon k\u00ebtu, shanset p\u00ebr sukses n\u00eb indet e tjera do t\u00eb rriten ndjesh\u00ebm.&#8221;<\/p>\n\n\n\n<p>Faza e par\u00eb (q\u00eb ka t\u00eb ngjar\u00eb t\u00eb p\u00ebrfshij\u00eb 10-20 persona) do t\u00eb testoj\u00eb kryesisht sigurin\u00eb: toleranc\u00ebn, p\u00ebrgjigjen imunitare t\u00eb trupit ndaj virusit dhe efektet an\u00ebsore t\u00eb mundshme. Efikasiteti do t\u00eb testohet m\u00eb von\u00eb, n\u00eb faz\u00ebn e dyt\u00eb t\u00eb provave klinike.<\/p>\n\n\n\n<p>&#8220;Mund t\u00eb duhen vite para se p\u00ebrdorimi rutin\u00eb te pacient\u00ebt t\u00eb jet\u00eb i mundur. Por vet\u00eb fakti q\u00eb teknologjia epigjenetike e rigjenerimit t\u00eb qelizave ka arritur n\u00eb provat njer\u00ebzore p\u00ebr her\u00eb t\u00eb par\u00eb \u00ebsht\u00eb nj\u00eb hap i r\u00ebnd\u00ebsish\u00ebm p\u00ebrpara p\u00ebr shkenc\u00ebn e plakjes&#8221;, shpjegon Zukhra Pavlova.<\/p>\n\n\n\n<p>ME KOMPETENC\u00cb<br>Olga Tkacheva , Doktore e Shkencave Mjek\u00ebsore, Profesoresh\u00eb, An\u00ebtare Korrespondente e Akademis\u00eb Ruse t\u00eb Shkencave, Drejtoresh\u00eb e Qendr\u00ebs Shkencore dhe Klinike Gerontologjike Ruse t\u00eb Universitetit Pirogov, Kryegjeriatrie e Ministris\u00eb s\u00eb Sh\u00ebndet\u00ebsis\u00eb Ruse dhe Presidente e Shoqat\u00ebs Ruse t\u00eb Gerontolog\u00ebve dhe Gjeriatricenjve, komentoi lajmin n\u00eb kanalin e saj n\u00eb Telegram.<\/p>\n\n\n\n<p>Studimi i faz\u00ebs I do t\u00eb p\u00ebrfshij\u00eb pacient\u00eb me glaukom\u00eb me k\u00ebnd t\u00eb hapur dhe neuropati optike iskemike anteriore jo-arteritike. K\u00ebto jan\u00eb s\u00ebmundje t\u00eb syrit q\u00eb lidhen me mosh\u00ebn p\u00ebr t\u00eb cilat aktualisht nuk ka trajtim specifik. Fokusi do t\u00eb jet\u00eb n\u00eb sigurin\u00eb, toleranc\u00ebn, p\u00ebrgjigjen imune dhe ndikimin e terapis\u00eb n\u00eb funksionin vizual.<\/p>\n\n\n\n<p>Nd\u00ebrsa q\u00ebllimi i prov\u00ebs s\u00eb par\u00eb \u00ebsht\u00eb t\u00eb kuptohet siguria e k\u00ebsaj metode p\u00ebr njer\u00ebzit, njer\u00ebzimi \u00ebsht\u00eb b\u00ebr\u00eb nj\u00eb hap m\u00eb af\u00ebr \u00ebndrr\u00ebs s\u00eb p\u00ebrt\u00ebritjes.<\/p>\n\n\n\n<p>T\u00eb kthejm\u00eb koh\u00ebn pas?<br>Gjat\u00eb 20 viteve t\u00eb fundit, biologjia e plakjes ka b\u00ebr\u00eb p\u00ebrparime t\u00eb konsiderueshme. \u00cbsht\u00eb b\u00ebr\u00eb e mundur t\u00eb matet mosha biologjike duke p\u00ebrdorur or\u00ebn epigjenetike, njihen dhjet\u00ebra &#8220;faktor\u00eb nxit\u00ebs&#8221; t\u00eb plakjes (nga shkurtimi i telomereve deri te inflamacioni) dhe tani \u00ebsht\u00eb e mundur t\u00eb ngadal\u00ebsohen k\u00ebta faktor\u00eb plakjeje te minjt\u00eb.<\/p>\n\n\n\n<p>ER-100 \u00ebsht\u00eb hera e par\u00eb q\u00eb nj\u00eb nga mjetet m\u00eb t\u00eb fuqishme (faktor\u00ebt Yamanaka) ka arritur te nj\u00eb njeri.<\/p>\n\n\n\n<p>Por ka ende shum\u00eb p\u00ebr t\u00eb b\u00ebr\u00eb: fazat e dyta dhe t\u00eb treta t\u00eb provave klinike, mij\u00ebra pacient\u00eb q\u00eb duhet t\u00eb marrin pjes\u00eb n\u00eb to dhe prova t\u00eb siguris\u00eb afatgjat\u00eb.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Administrata Amerikane e Ushqimit dhe Barnave (FDA) i ka dh\u00ebn\u00eb Life Biosciences miratimin p\u00ebr faz\u00ebn I t\u00eb provave klinike tek njer\u00ebzit t\u00eb nj\u00eb terapie gjenetike kund\u00ebr plakjes t\u00eb quajtur ER-100. Ato do t\u00eb fillojn\u00eb me trajtimin e ndryshimeve t\u00eb lidhura me mosh\u00ebn n\u00eb sy. Disa tashm\u00eb po e krahasojn\u00eb k\u00ebt\u00eb moment historik p\u00ebr shkenc\u00ebn e [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":5917,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[38],"tags":[],"class_list":{"0":"post-5916","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-stil"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Fillojn\u00eb Testet e Barnave Kund\u00ebr Plakjes n\u00eb SHBA - Kosova Times<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/kosovatimes.info\/index.php\/2026\/03\/21\/fillojne-testet-e-barnave-kunder-plakjes-ne-shba\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fillojn\u00eb Testet e Barnave Kund\u00ebr Plakjes n\u00eb SHBA - Kosova Times\" \/>\n<meta property=\"og:description\" content=\"Administrata Amerikane e Ushqimit dhe Barnave (FDA) i ka dh\u00ebn\u00eb Life Biosciences miratimin p\u00ebr faz\u00ebn I t\u00eb provave klinike tek njer\u00ebzit t\u00eb nj\u00eb terapie gjenetike kund\u00ebr plakjes t\u00eb quajtur ER-100. Ato do t\u00eb fillojn\u00eb me trajtimin e ndryshimeve t\u00eb lidhura me mosh\u00ebn n\u00eb sy. 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